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Provectus Reports on Shareholders Meeting
Friday June 19, 2009
-- Also Updates Its Website --

KNOXVILLE, Tenn.--(BUSINESS WIRE)--Provectus Pharmaceuticals, Inc. (OTCBB: PVCT, http://www.pvct.com), a development-stage oncology and dermatology biopharmaceutical company, held its 2009 Annual Meeting of Shareholders on Thursday, June 18, 2009 in Knoxville, Tennessee. Shareholders voted to re-elect the Company's five members of the Board of Directors, which is composed of three inside directors, and two outside directors. Outside directors who were re-elected were Stuart Fuchs of Gryffindor Capital Partners and Kelly M. McMasters, M.D., PhD., Chairman of the Department of Surgery and Chief of Surgery of the University of Louisville. Additionally, H. Craig Dees, Ph.D., CEO, Timothy C. Scott, President, and Eric A. Wachter, Ph.D., Executive Vice President-Pharmaceuticals, of Provectus were re-elected. Each Director serves a one-year term.

Dr. Dees, CEO of Provectus said, "We appreciate the confidence of our shareholders as Provectus continues to achieve its milestones for the development of PV-10 and PH-10. Our recently reported ASCO data support our mission to continue our quest to find a viable, safe and effective treatment for metastatic melanoma, and further our research towards that end. Having completed patient accrual in May for our phase 2 melanoma trial, we look forward to communicating additional results to the scientific community and investors in coming months."

Dr. Dees continued, "While our primary focus has been directed towards gaining regulatory approval for PV-10 in metastatic melanoma, data from oncology tests in animals indicates the drug has broad spectrum activity towards numerous tumor types. Further, to our knowledge PV-10 is the only intralesionally delivered agent that has been repeatedly demonstrated to induce removal of remote, untreated tumors through a bystander effect."

Dr. Dees concluded, "While our focus has been on developing PV-10 for metastatic melanoma, our scientific team and investigators are also working on developing PV-10 for other primary and metastatic cancers, such as those of the liver, as well as on PH-10 for atopic dermatitis and psoriasis, both of which are in Phase 2 trials. We look forward to furthering these important studies as well in the upcoming year."

Provectus has also updated its website (www.pvct.com), reflecting the Company's commitment to excellence, providing its investors and the scientific community with an easy-to-navigate means to get the most up-to-date information on the Company and its clinical trials. With improved functionality, it enables the public to get information they need on Provectus and its development pipeline.

About PV-10

PV-10 is a proprietary, injectable formulation of Rose Bengal, a compound that has been in use for nearly thirty years by ophthalmologists and optometrists to assess damage to the eye. It has also been used to detect ailments of the liver. Rose Bengal has an established safety history, a short half-life in the bloodstream, and is excreted via the liver and kidneys. Provectus has discovered a novel use for Rose Bengal based on the observation that it is selectively toxic to cancer calls via a process called chemoablation whereby cells undergo a form of cell death that mimics both features of necrosis and apoptosis.

About Provectus Pharmaceuticals, Inc. (www.pvct.com)

Provectus Pharmaceuticals is a development stage company that specializes in oncology and dermatology therapies that are safer, more effective, less invasive and more economical than conventional therapies. Provectus is currently conducting Phase 2 clinical trials of its proprietary drugs PV-10 as a therapy for metastatic melanoma and PH-10 as a topical treatment for psoriasis and atopic dermatitis. Information about these and the Company's other clinical trials can be found at the NIH registry, www.clinicaltrials.gov. The Company has received orphan drug designation from the FDA for its melanoma indication. Complementing their suite of proprietary drugs, Provectus has developed a number of intellectual properties and technologies in the areas of imaging, medical devices and biotechnology. For additional information about Provectus please visit the Company's website at www.pvct.com or contact Porter, LeVay & Rose, Inc.

FORWARD-LOOKING STATEMENTS: The forward-looking statements contained herein are subject to certain risks and uncertainties that could cause actual results to differ materially from those reflected in the forward-looking statements. Readers are cautioned not to place undue reliance on these forward-looking statements, which reflect management's analysis only as of the date hereof. The company undertakes no obligation to publicly revise these forward-looking statements to reflect events or circumstances that arise after the date thereof.

Contact:

Provectus Pharmaceuticals, Inc.
Peter R. Culpepper, CFO, 866-594-5999 #30
or
Porter, LeVay & Rose, Inc.
Marlon Nurse, 212-564-4700
VP – Investor Relations
or
Bill Gordon, 212-564-4700
SVP – Media Relations