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Melanoma Clinical Trial Update

Below is a group of photos for three separate lesions on a human with Stage III Metastatic Melanoma. Professor Thompson showed the photos relating to Lesion 1. In the series of photos, time passes from left to right, while the vertical direction shows the three injected lesions at each time point. Times are as follows:

(1st panel)
- immediately pre-treatment
- during injection
- 1 day post injection
(2nd panel)
- 7 days post injection
- 14 days post injection
- 28 days post injection

Progression appears to be identical to that observed in the Company's pre-clinical animal models.

NOTE:   THESE PHOTOS REPRESENT EARLY, PRELIMINARY DATA AND MAY NOT ACCURATELY REPRESENT FINAL OUTCOME FOR A PARTICULAR LESION.