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Research & Development

Product Pipeline

PV-10 for Recurrent Melanoma

PH-10 for Psoriasis

PV-10 for Atopic Dermatitis

PV-10 for Recurrent Breast Cancer

PV-10 for Metastatic Liver Cancer

Melanoma Clinical Trial Update

Clinical Trial Info   (at clinicaltrials.gov)

Compassionate Use Program for PV-10

Peer Reviewed Publications

"Intralesional Therapy With PV-10 (Rose Bengal) for in-Transit Melanoma.",

Journal of Surgical Oncology 2014;109:314-319 Feb 2014

PMID: 24510477

"In vitro inhibition of human liver cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT) enzymes by rose bengal: system-dependent effects on inhibitory potential",

Xenobiotica (Early Online 1-9) Jan 2014

PMID: 24405273

"Intralesional Injection of Rose Bengal Induces a Systemic Tumor-Specific Immune Response in Murine Models of Melanoma and Breast Cancer",

PLoS ONE 8(7): e68561. doi:10.1371/journal.pone.0068561, Jul 2013

PMID: 23874673

"Novel use of Rose Bengal (PV-10) in two cases of refractory scalp sarcoma",

ANZ Journal of Surgery 83:1-2:93, Jan 2013

PMID: 23350981

"Local and Intralesional Therapy of In-Transit Melanoma Mestasases",

Journal of Surgical Oncology   2011;104:391-396

PMID: 21858834

"Current and Planned Multicenter Trials for Patients WIth Primary or Metastatic Melanoma",

Journal of Surgical Oncology   2011;104:430-437

PMID: 21858839

"A novel treatment for metastatic melanoma with intralesional rose bengal and radiotherapy: a case series",

Melanoma Research 20:48, Jan 2010

PMID: 20009957

"Chemoablation of metastatic melanoma using intralesional Rose Bengal",

Melanoma Research 18:405, Dec 2008

PMID: 18830132

"Systemic Phototoxicity following Intralesional Rose Bengal for Subcutaneous Melanoma Metastases",

Dermatology 2008;216:361-362,   Feb 2008

PMID: 18292654

"Topical Rose Bengal: Pre-Clinical Evaluation of Pharmacokinetics and Safety",

Lasers in Surgery and Medicine Vol. 32, No. 2, 2003

PMID: 12561042

"Imaging Photosensitizer Distribution and Pharmacology using Multiphoton Microscopy",

In "Functional Imaging and Optical Manipulation of Living Cells and Tissues".

SPIE Paper 4622A-14,   Jan 2002

SDLID: 872032

"Functional Imaging of Photosensitizers using Multiphoton Microscopy",

In "Multiphoton Microscopy in the Biomedical Sciences II".

SPIE Paper 4620-29,   Jan 2002

SDLID: 871867

"Treatment of murine cutaneous melanoma with near infrared light",

Photochemistry and Photobiology, 75(3):296-301,   Mar 2002

PMID: 11950096

Additional Peer Reviewed Literature

"Rose Bengal suppresses gastric cancer cell proliferation via apoptosis and inhibits nitric oxide formation in macrophages.",

Journal of Immunotoxicology (online ahead of print) Feb 2014

PMID: 24575814

"Selective toxicity of rose bengal to ovarian cancer cells in vitro",

Int J Physiol Pathophysiol Pharmacol 2012;4(2):99-107,   Jun 2012

PMID: 22837809

"Intralesional agents in the management of cutaneous malignancy: a review.",

Journal of the American Academy of Dermatology 64(2):413-22,   Feb 2011

PMID: 20334952

White Papers

"PV-10 Moves Forward",

W. Alexander,   Jun 2013

Scientific Presentations

"Locoregional Disease Control in Metastatic Melanoma: Exploratory Analyses From Phase 2 Testing of Intralesional Rose Bengal",

European Cancer Congress 2013, Abstract No. 3.755,   Sep 2013

"Rose Bengal - Phototoxicity versus Intrinsic Cytotoxicity"

8th World Congress of Melanoma, Free Communications 4: Melanoma Treatment, Abstract FC-021,   Jul 2013

"Intralesional Injection with PV-10 Induces a Systemic Anti-tumor Immune Response in Murine Models of Breast Cancer and Melanoma",

American Association for Cancer Research Annual Meeting, Abstract #1248,   Apr 2013

"Combination of PV-10 Immuno-chemoablation and Systemic anti-CTLA-4 Antibody Therapy in Murine Models of Melanoma",

American Association for Cancer Research Annual Meeting, Abstract #4755,   Apr 2013

"Generation of an Antitumor Response and Immunity Using a Small Molecule Drug (PV-10)",

Society for Immunotherapy of Cancer 27th Annual Meeting [ poster ]

Journal of Immunotherapy Vol. 35, No. 9,   Nov 2012

"Immuno-chemoablation of metastatic melanoma with intralesional rose bengal",

European Society for Medical Oncology 2012 Congress,   Oct 2012

"Intralesional Injection of Melanoma with Rose Bengal Induces Regression of Untreated Synchronous Melanoma In a Murine Model",

Society of Surgical Oncology Annual Meeting,   Mar 2012

"Chemoablation of Metastatic Melanoma with Rose Bengal (PV-10)"

American Society of Clinical Oncology, Jun 2010

"Chemoablation of Melanoma with Intralesional Rose Bengal (PV-10)"

American Society of Clinical Oncology, Jun 2009

"Rose Bengal induces dual modes of cell death in melanoma cells and has clinical activity against melanoma",

Melanoma Research 16(Suppl 1):S8, Sep 2006

Other Publications

"PV-10 in Advanced Melanoma: High Response Rates, Evidence of Systemic Response",

Cancer Watch, Vol. 22:155-156,   Oct 2013

"Rose Bengal-Based Drug Kills Both Primary and Secondary Melanoma Tumors",

Bio Research International, Vol.18 No.5,   Sep 2013

"Back to Phase 1: Understanding Systemic Effects of PV-10",

Cancer Watch, Vol. 22:21-23,   Feb 2013

"ESMO 2012: PV-10 shows sustained response in melanoma",

ecancer news   Oct 2012

"Immunotherapy Update: Ipilimumab and Intralesional Therapies",

Cancer Watch, Vol. 21:135-136,   Sep 2012

"Provectus looks to Phase III with positive melanoma data",

Scrip Intelligence,   Jun 2012

"Metastatic Melanoma: A Murine Study Confirming an Immune Response with PV-10",

Cancer Watch, Vol. 21:86-89,   Jun 2012

"PV-10, aka Rose Bengal: Intralesional Therapy For Metastatic Melanoma",

The Melanoma Letter, Vol. 30, No. 1:5-7,   May 2012

"Rose Bengal - More Than Just a Red Food Dye?",

The North Carolina Osteopathic Medical Association News:25,   Mar 2012

"Clinical News",

BioCentury,   March 26, 2012

"Individualized Local Treatment Strategies for In-Transit Melanoma",

ONCOLOGY,   Feb 2012

"PV-10: A Melanoma Therapeutic in the Pipeline",

Practical Dermatology, January 2012:41-42,   Jan 2012

"New Agents Stir Interest in Intralesional Therapy for Cutaneous Metastatic Melanoma",

Cancer Watch, Vol. 20, No. 9:139-140,   Sep 2011

"One-year Findings in Metastatic Melanoma Confirm Rose Bengal Benefit",

The Oncology Pharmacist, Vol. 4, No. 1:139-140,   Feb 2011

"Slovenian Woman Travels to St. Luke's Cancer Center to Receive Treatment for Advanced Melanoma with Dr. Agarwala",

St. Luke's Cancer Connection Letter,   Jan 2011

"Melanoma: Rose bengal scores, ipilimumab sees delay",

Oncology News International, Vol. 19, No. 12:139-140,   Dec 2010

"Compassionate Input to Phase III",

Trials In Focus,   December 6, 2010

"Chemoablation of Metastatic Melanoma",

Cancer Watch, Vol 19, No. 11:164-164   Nov 2010

"Chemoablation of Metastatic Melanoma with PV-10",

Presentation at 4th Interdisciplinary Melanoma & Skin Cancer Centres Meeting, Sydney, AU   Nov 2010

"Skin cancer tumors busted with red dye 'tattoo' trial",

The Courier-Mail   Nov. 4, 2010

"High Responses in Melanoma for Wool Dye/Ocular Stain Rose Bengal",

The Oncology Pharmacist, Vol. 3 No. 7   Oct 2010

"Rose Bengal: From a Wool Dye to a Cancer Therapy",

Pharmacy and Therapeutics, Vol. 35, No. 8:469-469   Aug 2010

"Trial heralding a new day for melanoma meets with guarded enthusiasm"",

Oncology News International, Vol. 19, No. 7   Jul 2010

"Robust Response in Metastatic Melanoma to Rose Bengal (PV-10)",

Cancer Watch, Vol. 19, No. 7:109-110   Jul 2010

"Promising Data on Ipilimumab and Other Investigational Melanoma Therapies",

Practical Dermatology, Vol. 7, No. 6:24-25   Jun 2010

"New era in metastatic melanoma",

Molecular Oncology, Vol. 4, N0. 2:91-97   Apr 2010

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